In terms of how you interact with it day to day, no. And that’s because the Distro in that sense matters less than the desktop environment. Since DEs are fundamentally distro agnostic, most distros give a person the option for multiple choices in that regard, so it doesn’t really matter if you’re using Ubuntu, Arch, Fedora, etc… what matters from a usage perspective is if you’re using KDE, or Gnome, or XFCE, etc…
Under the hood there’s a lot of differences in how each one chooses to do things, but I wouldn’t call one of them better or worse than any other and for the most part can be ignored.
My advice would be narrow it down to one choice; and that’s your package manager. That’s really where most of the difference lies. Find the one that you find easiest to use (Apt, Pacman/Pamac, DNF, Zypper) and that’s where you land until you’re comfortable.
In terms of how you interact with it day to day, no. And that’s because the Distro in that sense matters less than the desktop environment. Since DEs are fundamentally distro agnostic, most distros give a person the option for multiple choices in that regard, so it doesn’t really matter if you’re using Ubuntu, Arch, Fedora, etc… what matters from a usage perspective is if you’re using KDE, or Gnome, or XFCE, etc…
Under the hood there’s a lot of differences in how each one chooses to do things, but I wouldn’t call one of them better or worse than any other and for the most part can be ignored.
My advice would be narrow it down to one choice; and that’s your package manager. That’s really where most of the difference lies. Find the one that you find easiest to use (Apt, Pacman/Pamac, DNF, Zypper) and that’s where you land until you’re comfortable.